While the Restylane line smooths away facial wrinkles and folds ( Restylane, Restylane Lyft, Restylane Refyne, Restylane Defyne ), provides subtle lip enhancement (Restylane, Restylane Silk), smooths the lines around the mouth (Restylane Silk), adds lift and volume to the cheeks (Restylane Lyft), and helps reverse the signs of volume loss in the back of the hands (Restylane Lyft). The Restylane line of products is formulated to act like your body’s own naturally occurring hyaluronic acid, restoring volume to your skin.
There are some temporary, potential side effects associated with JUVÉDERM® products. These include injection-site reactions:
Injection site responses across the collection are mostly mild-to-moderate in severity.
These reactions may occur immediately, or may be delayed, and can last for up to a week. Injection in the lip may cause more swelling and bruising due to the unique physiology of this area. As with any injection, there is a small risk of infection. This is not a complete list of side effects. If inflammatory reactions persist for more than one week, or if any other side effects develop, seek medical attention as soon as possible.
With full treatment, you can see lasting results for up to 18 months in nasolabial folds with Restylane;10 up to 12 months in the cheeks, up to 6 months in the back of the hands, and up to 6 months in facial wrinkles and folds, such as nasolabial folds, with Restylane Lyft;3 6 months for lips and perioral rhytids with Restylane Silk;11 and up to 12 months in the facial wrinkles and folds (such as nasolabial folds and marionette lines) with Restylane Refyne and Restylane Defyne.12,13
Restylane Silk: In clinical studies, the results of Restylane Silk lasted approximately 6 months following treatment. In a U.S. clinical trial involving 221 mostly female subjects, 98% of subjects reported a visible improvement in lip fullness in upper and lower lip (combined) 14 days after injection, and 77% still had lip improvement at 6 months following injection.11
Restylane Lyft: In a clinical trial involving 150 subjects, blinded evaluators observed that 90% of subjects treated with Restylane Lyft showed an improvement in fullness in the right and left midface areas (combined) at 2 months, and 54% of subjects showed an improvement at 12 months. Additionally, 95% of subjects reported that they were satisfied with the appearance of their midface at 2 months, and 73% of subjects were satisfied at 12 months.3 In a clinical trial involving 89 treated subjects, blinded evaluators observed that 86% of subjects* treated with Restylane Lyft showed an improvement in volume of the back of the hands at 3 months, and 76% of subjects* showed an improvement at 6 months. Improvement was defined as subjects with a Merz Hand Grading Scale (MHGS) score of ≥1 grade from baseline by the blinded evaluator’s live assessment.3
*n=85 subjects treated.
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